Chloe Melas has opened up about a deeply personal health struggle she’s faced for 15 years — one that has led to countless hospital visits, surgeries, and years of uncertainty.
The Today host sat down on the show to discuss her new book, The Girl’s Guide to Guts, sharing her journey with ulcerative colitis, a chronic form of inflammatory bowel disease (IBD).
“For 15 years, I’ve been living with ulcerative colitis,” Chloe revealed. “It’s a form of IBD, like Crohn’s, and over a decade I’ve gone through surgeries, colonoscopies, and many hospitalizations without feeling truly seen or understood.”
Her memoir, co-written with best friend and New York Times bestselling author Judy Batalion, combines candid storytelling with expert advice. “It’s funny and sad,” Chloe explained. “But most importantly, we hope it helps millions of girls love their guts and know they are not alone.”
The book addresses the rising awareness of IBD, IBS, and colon cancer, offering both a personal lens and practical guidance for readers.
Fans quickly flooded social media with messages of support. One wrote, “You’re amazing.” Another commented, “I’ve had ulcerative colitis for 40 years and finally someone is talking about it.”
Chloe’s hope is clear: to bring visibility to a silent struggle and help others facing similar challenges find their community, support, and strength.






